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Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.
The clinical significance of these findings is unknown.
Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.
A portion of the drug is excreted unchanged in the urine, while the rest is metabolized via the liver. V.: Treatment of moderate to severe allergic reactions: 5 mg/kg/day or 150 mg/m 2 /day in divided doses every 6-8 hours, not to exceed 300 mg/day Minor allergic rhinitis or motion sickness: 2 to /= 12 years: 25 mg every 4 hours; maximum 150 mg/day I. V.: Treatment of dystonic reactions: 0.5-1 mg/kg/dose Adults: Oral: 25-50 mg every 6-8 hours Minor allergic rhinitis or motion sickness: 25-50 mg every 4-6 hours; maximum: 300 mg/day Moderate to severe allergic reactions: 25-50 mg every 4 hours, not to exceed 400 mg/day Nighttime sleep aid: 50 mg at bedtime I. V.: 10-50 mg in a single dose every 2-4 hours, not to exceed 400 mg/day Dystonic reaction: 50 mg in a single dose; may repeat in 20-30 minutes if necessary Topical: For external application, not longer than 7 days Supplied Elixir, as hydrochloride: 12.5 mg/5 m L (480 m L) Caplet, as hydrochloride: 25 mg, 50 mg Capsule, as hydrochloride: 25 mg, 50 mg Injection, solution, as hydrochloride: 50 mg/m L (1 m L) Solution, topical, as hydrochloride [spray] (Benadryl® Itch Stopping Extra Strength): 2% (60 m L) [contains zinc acetate 0.1%] Tablet, chewable, as hydrochloride (Benadryl® Children's Allergy): 12.5 mg [contains phenylalanine 4.2 mg/tablet; grape flavor] Tablet, orally-disintegrating, as citrate (Benadryl® Children's Allergy Fastmelt®): 19 mg [equivalent to diphenhydramine hydrochloride 12.5 mg; contains phenylalanine 4.5 mg/tablet and soy protein isolate; cherry flavor] Adult (usual): Antiemetic: I. Anxiety: Oral: 25-100 mg 4 times/day; maximum: 600 mg/day. Anesthesia adjunct: 25-50 mg IM or IV prior to surgery. Nausea and vomiting: 12.5-25 mg orally ,rectally, IV or IM every 4 to 6 hrs. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.
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Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.
Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.
A dose of 60 mg once daily is recommended as the starting dose in patients with decreased renal function Mechanism of Action Fexofenadine hydrochloride, the major active metabolite of terfenadine, is an antihistamine with selective peripheral H1-receptor antagonist activity.
Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects.
Dosing:: one tablet twice daily for adults and children 12 years of age and older (should be taken on an empty stomach).
A dose of one tablet once daily is recommended as the starting dose in patients with decreased renal function.
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